Botanicals and zinc in chewable tablets for upper GI health.
Symptoms of upper gastrointestinal discomfort are among the most common patient complaints. Supporting the healing process of esophageal, gastric, and abdominal tissues requires more than just treating symptoms. Deglycyrrhizinated licorice (DGL) is rich in flavonoids and chalcones, among other constituents, that favorably yet safely influence mucosal health by a number of mechanisms. Slippery elm bark contains a mucilage component with soothing properties ideally suited for protecting the tissues of the upper gastrointestinal tract. Zinc has several functions essential for healing disturbed tissues, including those of the upper digestive tract. These therapies are combined in a pleasant-tasting chewable tablet, since capsules do not allow the development of the soothing coating action required for maximal effectiveness.
- Deglycyrrhizinated licorice (DGL) contains flavonoids and chalcones exhibiting multiple protective effects on gastric mucosal tissues (Comp Biochem Physiol 1996;113C:17-21;Planta Med 1992;58:389-93; Eur J Pharmacol1981;72:219-25), but it is free of potentially hazardous glycyrrhizin that occurs naturally in licorice (Food Chem Toxicol 1993;31:303-12).
- DGL has repeatedly demonstrated effectiveness in supporting normal growth and repair processes in the upper digestive tract according to controlled human trials (Gut 1985; 26:599-602; Gut 1982;23:545-51).
- The topical benefits of DGL (J Assoc Phys India1989;37:647) and the clinical failure of forms that did not interact with saliva (Gut1978;19:779-82; Practitioner 1975;215:787-92) emphasize the necessity of a chewable DGL tablet.
- Slippery elm bark contains a mucilage component with soothing properties ideally suited for protecting the tissues of the upper gastrointestinal tract.
- Zinc has several functions essential for healing, and has significantly improved growth and repair processes in the upper digestive tract compared with placebo in double-blind research (Med J Aust 1975;2:793-6).
Gastrointestinal and Digestive Support
Suggested use for adults: Two chewable tablets 30 minutes before meals, three times daily, or as directed.
Karuna products reflect our commitment to providing you with herbal and nutritional supplements free of preservatives, excipients or other additives problematic for the allergic or sensitive patient. Tablets and capsules contain no added sugars, artificial flavorings or preservatives. Disintegration time for all tablets is QC verified at thirty minutes or less unless otherwise indicated. Our search for the finest natural ingredients extends across six continents, and organic sources provide an increasingly larger percentage of our ingredient choices.
Solubility and bioavailability are primary considerations in the design of Karuna capsules and tablets, and we use hypoallergenic ingredients to fill any additional space. Where necessary, cellulose (vegetable fiber from white birch) is used as a disintegrant, and vegetable stearines are utilized as lubricants. For tablets, aqueous cellulose coating is used unless non-allergenic food glaze or pH-sensitive enteric coatings are required by the nature of the tablet. Amino acid chelates are from barley or rice, hydrolyzed protein or free amino acids.
For herbal ingredients, standardized botanical extracts are used whenever possible, assuring reliable potency. Herbal concentrates are used in many formulas and are indicated in parentheses. For example, a (4:1) herbal extract represents a four-fold concentrate of the starting material, with four pounds of raw herb being required to produce one pound of extract. The resulting activity will be approximately four times that of the powdered, unconcentrated herb.